5-Amino -1MQ 50mg
5-Amino-1MQ – 50mg
Research Grade | Small Molecule Powder
For Laboratory Research Use Only. Not for Human or Veterinary Use.
5-Amino-1-methylquinolinium (5-Amino-1MQ) is a synthetic small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). It is widely studied in metabolic and obesity-related research for its role in regulating NAD⁺ metabolism, energy homeostasis, and cellular methylation pathways.
This compound is supplied as a high-purity, lyophilized powder suitable for in-vitro and preclinical research applications.
Chemical Information
Compound Name: 5-Amino-1-methylquinolinium iodide Synonyms: 5-Amino-1MQ, NNMT inhibitor Compound Class: Small-molecule metabolic modulator
Molecular Formula: C₁₁H₁₂N₂⁺
Molecular Weight: 172.23 g/mol (free base); 50mg fill size
CAS Number: 1710418-42-7
Purity: ≥99% (HPLC verified)
Appearance: White to off-white crystalline powder
Solubility: Soluble in Bacteriostatic Water, DMSO and aqueous laboratory buffers
Fill Size: 50 mg per vial
Mechanism & Research Context
5-Amino-1MQ acts as a selective NNMT inhibitor:
Reduces nicotinamide N-methyltransferase activity in cellular models
Modulates NAD⁺ metabolism and S-adenosylmethionine (SAM) pathways
Used to study metabolic regulation, energy expenditure, and obesity mechanisms in preclinical research
Potential Research Applications
NNMT pathway studies in metabolic tissues
NAD⁺ and methylation pathway regulation
Energy homeostasis and obesity research
Preclinical assays for metabolic disease and mitochondrial function
Cellular signaling and pharmacology studies
